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Noninvasive Imaging of Therapeutic Gene Expression Using a Bi-directional Transcriptional Amplification Strategy
Tumor-specific promoters that limit transgene expression to tumors play a vital role in cancer gene therapy. Although tumor specific, the human Survivin promoter (pSurv) is a poor activator of transcription. A bi-directional Two Step Transcriptional Amplification (TSTA) system was designed to enhanc...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3195556/ https://ncbi.nlm.nih.gov/pubmed/18766175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.180 |
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