Intratumoral versus Intravenous Gene Therapy Using a Transcriptionally Targeted Viral Vector in an Orthotopic Hepatocellular Carcinoma Rat Model

PURPOSE: To evaluate the feasibility of intratumoral delivery of adenoviral vector carrying a bidirectional two-step transcriptional amplification (TSTA) system to amplify transcriptional strength of cancer-specific Survivin promoter in a hepatocellular carcinoma model. MATERIALS AND METHODS: MCA-RH...

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Main Authors: Kim, Young Il, Ahn, Byeong-Cheol, Ronald, John A., Katzenberg, Regina, Singh, Abhinav, Paulmurugan, Ramasamy, Ray, Sunetra, Gambhir, Sanjiv S., Hofmann, Lawrence V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132166/
https://ncbi.nlm.nih.gov/pubmed/22387029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jvir.2012.01.053
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