Biochemical Characterization of Sfh-I, a Subclass B2 Metallo-β-Lactamase from Serratia fonticola UTAD54

The subclass B2 metallo-β-lactamase (MBL) Sfh-I from Serratia fonticola UTAD54 was cloned and overexpressed in Escherichia coli. The recombinant protein binds one equivalent of zinc, as shown by mass spectrometry, and preferentially hydrolyzes carbapenem substrates. However, compared to other B2 MBL...

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Autori principali: Fonseca, Fátima, Arthur, Christopher J., Bromley, Elizabeth H. C., Samyn, Bart, Moerman, Pablo, Saavedra, Maria José, Correia, António, Spencer, James
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195014/
https://ncbi.nlm.nih.gov/pubmed/21876065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00429-11
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