Increased Frequency of Regulatory T Cells Accompanies Increased Immune Activation in Rectal Mucosae of HIV-Positive Noncontrollers

Gut-associated lymphoid tissue (GALT) is a major site of HIV replication and CD4(+) T cell depletion. Furthermore, microbial translocation facilitated by mucosal damage likely contributes to the generalized immune activation observed in HIV infection. Regulatory T cells (Treg) help maintain homeosta...

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Détails bibliographiques
Auteurs principaux: Shaw, Julia M., Hunt, Peter W., Critchfield, J. William, McConnell, Delandy H., Garcia, Juan Carlos, Pollard, Richard B., Somsouk, Ma, Deeks, Steven G., Shacklett, Barbara L.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2011
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194952/
https://ncbi.nlm.nih.gov/pubmed/21880771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05608-11
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