Immunodominant HIV-Specific CD8(+) T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers

Previous studies have suggested that polyfunctional mucosal CD8(+) T-cell responses may be a correlate of protection in HIV controllers. Mucosal T-cell breadth and/or specificity may also contribute to defining protective responses. In this study, rectal CD8(+) T-cell responses to HIV Gag, Env, and...

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Detalhes bibliográficos
Principais autores: Ferre, April L., Lemongello, Donna, Hunt, Peter W., Morris, Megan M., Garcia, Juan Carlos, Pollard, Richard B., Yee, Hal F., Martin, Jeffrey N., Deeks, Steven G., Shacklett, Barbara L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937770/
https://ncbi.nlm.nih.gov/pubmed/20668079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00803-10
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