Magnitude and Complexity of Rectal Mucosa HIV-1-Specific CD8+ T-Cell Responses during Chronic Infection Reflect Clinical Status

BACKGROUND: The intestinal mucosa displays robust virus replication and pronounced CD4+ T-cell loss during acute human immunodeficiency virus type 1 (HIV-1) infection. The ability of HIV-specific CD8+ T-cells to modulate disease course has prompted intensive study, yet the significance of virus-spec...

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Detalhes bibliográficos
Main Authors: Critchfield, J. William, Young, Delandy H., Hayes, Timothy L., Braun, Jerome V., Garcia, Juan C., Pollard, Richard B., Shacklett, Barbara L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570490/
https://ncbi.nlm.nih.gov/pubmed/18974782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003577
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