Cocaine-Induced Adaptations in Cellular Redox Balance Contributes to Enduring Behavioral Plasticity

Impaired glutamate homeostasis in the nucleus accumbens has been linked to cocaine relapse in animal models, and results in part from cocaine-induced downregulation of the cystine–glutamate exchanger. In addition to regulating extracellular glutamate, the uptake of cystine by the exchanger is a rate...

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Hlavní autoři: Uys, Joachim D, Knackstedt, Lori, Hurt, Phelipe, Tew, Kenneth D, Manevich, Yefim, Hutchens, Steven, Townsend, Danyelle M, Kalivas, Peter W
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194081/
https://ncbi.nlm.nih.gov/pubmed/21796101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.143
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