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Diazeniumdiolate Mediated Nitrosative Stress Alters Nitric Oxide Homeostasis through Intracellular Calcium and S-Glutathionylation of Nitric Oxide Synthetase
BACKGROUND: PABA/NO is a diazeniumdiolate that acts as a direct nitrogen monoxide (NO) donor and is in development as an anticancer drug. Its mechanism of action and effect on cells is not yet fully understood. METHODOLOGY/PRINCIPAL FINDINGS: We used HPLC and mass spectrometry to identify a primary...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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Public Library of Science
2010
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2994766/ https://ncbi.nlm.nih.gov/pubmed/21152397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014151 |
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