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Diazeniumdiolate Mediated Nitrosative Stress Alters Nitric Oxide Homeostasis through Intracellular Calcium and S-Glutathionylation of Nitric Oxide Synthetase

BACKGROUND: PABA/NO is a diazeniumdiolate that acts as a direct nitrogen monoxide (NO) donor and is in development as an anticancer drug. Its mechanism of action and effect on cells is not yet fully understood. METHODOLOGY/PRINCIPAL FINDINGS: We used HPLC and mass spectrometry to identify a primary...

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Bibliografiske detaljer
Main Authors: Manevich, Yefim, Townsend, Danyelle M., Hutchens, Steven, Tew, Kenneth D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994766/
https://ncbi.nlm.nih.gov/pubmed/21152397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014151
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