S-Glutathionylated Serine Proteinase Inhibitors as Plasma Biomarkers in Assessing Response to Redox-Modulating Drugs

Many cancer drugs impact cancer cell redox regulatory mechanisms and disrupt redox homeostasis. Pharmacodynamic biomarkers that measure therapeutic efficacy or toxicity could improve patient management. Using immunoblot analyses and mass spectrometry, we identified that serpins A1 and A3 were S-glut...

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Main Authors: Grek, Christina L., Townsend, Danyelle M., Uys, Joachim D., Manevich, Yefim, Coker, Woodrow J., Pazoles, Christopher J., Tew, Kenneth D.
格式: Artigo
語言:Inglês
出版: 2012
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151169/
https://ncbi.nlm.nih.gov/pubmed/22406622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-4088
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