Diagnostic Testing for IDH1 and IDH2 Variants in Acute Myeloid Leukemia: An Algorithmic Approach Using High-Resolution Melting Curve Analysis

Isocitrate dehydrogenase 1 (IDH1) and IDH2 mutations and polymorphism are reported in 5% to 15% of acute myeloid leukemia (AML) cases, with G105 and R132 of IDH1 and R140 and R172 of IDH2 known to be clinically significant. Current Sanger sequencing assays to detect IDH mutations are labor intensive...

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Detalhes bibliográficos
Main Authors: Patel, Keyur P., Barkoh, Bedia A., Chen, Zhao, Ma, Deqin, Reddy, Neelima, Medeiros, L. Jeffrey, Luthra, Rajyalakshmi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194054/
https://ncbi.nlm.nih.gov/pubmed/21889610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2011.06.004
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