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Using Molecular Dynamics to Probe the Structural Basis for Enhanced Stability in Thermal Stable Cytochromes P450

High temperature molecular dynamics (MD) has been used to assess if MD can be employed as a useful tool for probing the structural basis for enhanced stability in thermal stable cytochromes P450. CYP119, the most thermal stable P450 known, unfolds more slowly during 500K MD simulations compared to P...

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Bibliografski detalji
Glavni autori: Meharenna, Yergalem T., Poulos, Thomas L.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193997/
https://ncbi.nlm.nih.gov/pubmed/20593793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100929x
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