Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

By studying the loci that contribute to human longevity, we aim to identify mechanisms that contribute to healthy aging. To identify such loci, we performed a genome-wide association study (GWAS) comparing 403 unrelated nonagenarians from long-living families included in the Leiden Longevity Study (...

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Detalhes bibliográficos
Main Authors: Deelen, Joris, Beekman, Marian, Uh, Hae-Won, Helmer, Quinta, Kuningas, Maris, Christiansen, Lene, Kremer, Dennis, van der Breggen, Ruud, Suchiman, H Eka D, Lakenberg, Nico, van den Akker, Erik B, Passtoors, Willemijn M, Tiemeier, Henning, van Heemst, Diana, de Craen, Anton J, Rivadeneira, Fernando, de Geus, Eco J, Perola, Markus, van der Ouderaa, Frans J, Gunn, David A, Boomsma, Dorret I, Uitterlinden, André G, Christensen, Kaare, van Duijn, Cornelia M, Heijmans, Bastiaan T, Houwing-Duistermaat, Jeanine J, Westendorp, Rudi G J, Slagboom, P Eline
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193372/
https://ncbi.nlm.nih.gov/pubmed/21418511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2011.00705.x
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