Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

By studying the loci that contribute to human longevity, we aim to identify mechanisms that contribute to healthy aging. To identify such loci, we performed a genome-wide association study (GWAS) comparing 403 unrelated nonagenarians from long-living families included in the Leiden Longevity Study (...

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Hlavní autoři: Deelen, Joris, Beekman, Marian, Uh, Hae-Won, Helmer, Quinta, Kuningas, Maris, Christiansen, Lene, Kremer, Dennis, van der Breggen, Ruud, Suchiman, H Eka D, Lakenberg, Nico, van den Akker, Erik B, Passtoors, Willemijn M, Tiemeier, Henning, van Heemst, Diana, de Craen, Anton J, Rivadeneira, Fernando, de Geus, Eco J, Perola, Markus, van der Ouderaa, Frans J, Gunn, David A, Boomsma, Dorret I, Uitterlinden, André G, Christensen, Kaare, van Duijn, Cornelia M, Heijmans, Bastiaan T, Houwing-Duistermaat, Jeanine J, Westendorp, Rudi G J, Slagboom, P Eline
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2011
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193372/
https://ncbi.nlm.nih.gov/pubmed/21418511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2011.00705.x
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