Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

A set of currently known alleles increasing the risk for coronary artery disease, cancer, and type 2 diabetes as identified by genome-wide association studies was tested for compatibility with human longevity. Here, we show that nonagenarian siblings from long-lived families and singletons older tha...

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Detalhes bibliográficos
Main Authors: Beekman, Marian, Nederstigt, Christa, Suchiman, H. Eka D., Kremer, Dennis, van der Breggen, Ruud, Lakenberg, Nico, Alemayehu, Wendimagegn Ghidey, de Craen, Anton J. M., Westendorp, Rudi G. J., Boomsma, Dorret I., de Geus, Eco J. C., Houwing-Duistermaat, Jeanine J., Heijmans, Bastiaan T., Slagboom, P. Eline
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964208/
https://ncbi.nlm.nih.gov/pubmed/20921414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003540107
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