A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-α levels

Cytokines are major immune system regulators. Previously, innate cytokine profiles determined by lipopolysaccharide stimulation were shown to be highly heritable. To identify regulating genes in innate immunity, we analyzed data from a genome-wide linkage scan using microsatellites in osteoarthritis...

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Autori principali: Bos, Steffan D, Lakenberg, Nico, van der Breggen, Ruud, Houwing-Duistermaat, Jeanine J, Kloppenburg, Margreet, de Craen, Anton JM, Beekman, Marian, Meulenbelt, Ingrid, Slagboom, P Eline
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987381/
https://ncbi.nlm.nih.gov/pubmed/20407468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2010.52
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