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The TRAF-associated protein TANK facilitates cross-talk within the IκB kinase family during Toll-like receptor signaling

Toll-like receptor (TLR) ligands that signal via TIR-domain-containing adapter-inducing IFNβ (TRIF) activate the IκB kinase (IKK)-related kinases, TRAF associated NFκB activator (TANK)-binding kinase-1 (TBK1) and IKKε, which then phosphorylate IRF3 and induce the production of IFNβ. Here we show tha...

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Autors principals: Clark, Kristopher, Takeuchi, Osamu, Akira, Shizuo, Cohen, Philip
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193242/
https://ncbi.nlm.nih.gov/pubmed/21949249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114194108
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