TRAF Family Member-associated NF-κB Activator (TANK) Is a Negative Regulator of Osteoclastogenesis and Bone Formation

The differentiation of bone-resorbing osteoclasts is induced by RANKL signaling, and leads to the activation of NF-κB via TRAF6 activation. TRAF family member-associated NF-κB activator (TANK) acts as a negative regulator of Toll-like receptors (TLRs) and B-cell receptor (BCR) signaling by inhibitin...

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Detalhes bibliográficos
Main Authors: Maruyama, Kenta, Kawagoe, Tatsukata, Kondo, Takeshi, Akira, Shizuo, Takeuchi, Osamu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436591/
https://ncbi.nlm.nih.gov/pubmed/22773835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.347799
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