Identification of an imprinted master trans-regulator at the KLF14 locus related to multiple metabolic phenotypes

Genome-wide association studies have identified many genetic variants associated with complex traits. However, at only a minority of loci have the molecular mechanisms mediating these associations been characterized. In parallel, whilst cis-regulatory patterns of gene expression have been extensivel...

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Main Authors: Small, Kerrin S., Hedman, Åsa K., Grundberg, Elin, Nica, Alexandra C., Thorleifsson, Gudmar, Kong, Augustine, Thorsteindottir, Unnur, Shin, So-Youn, Richards, Hannah B., Soranzo, Nicole, Ahmadi, Kourosh R., Lindgren, Cecilia M., Stefansson, Kari, Dermitzakis, Emmanouil T., Deloukas, Panos, Spector, Timothy D., McCarthy, Mark I.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192952/
https://ncbi.nlm.nih.gov/pubmed/21572415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.833
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