Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population

Age-related changes in DNA methylation have been implicated in cellular senescence and longevity, yet the causes and functional consequences of these variants remain unclear. To elucidate the role of age-related epigenetic changes in healthy ageing and potential longevity, we tested for association...

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Hauptverfasser: Bell, Jordana T., Tsai, Pei-Chien, Yang, Tsun-Po, Pidsley, Ruth, Nisbet, James, Glass, Daniel, Mangino, Massimo, Zhai, Guangju, Zhang, Feng, Valdes, Ana, Shin, So-Youn, Dempster, Emma L., Murray, Robin M., Grundberg, Elin, Hedman, Asa K., Nica, Alexandra, Small, Kerrin S., Dermitzakis, Emmanouil T., McCarthy, Mark I., Mill, Jonathan, Spector, Tim D., Deloukas, Panos
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330116/
https://ncbi.nlm.nih.gov/pubmed/22532803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002629
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