The Presence of Methylation Quantitative Trait Loci Indicates a Direct Genetic Influence on the Level of DNA Methylation in Adipose Tissue

Genetic variants that associate with DNA methylation at CpG sites (methylation quantitative trait loci, meQTLs) offer a potential biological mechanism of action for disease associated SNPs. We investigated whether meQTLs exist in abdominal subcutaneous adipose tissue (SAT) and if CpG methylation ass...

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Detalhes bibliográficos
Main Authors: Drong, Alexander W., Nicholson, George, Hedman, Åsa K., Meduri, Eshwar, Grundberg, Elin, Small, Kerrin S., Shin, So-Youn, Bell, Jordana T., Karpe, Fredrik, Soranzo, Nicole, Spector, Tim D., McCarthy, Mark I., Deloukas, Panos, Rantalainen, Mattias, Lindgren, Cecilia M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576415/
https://ncbi.nlm.nih.gov/pubmed/23431366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055923
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