Multiple sites on prostaglandin cyclooxygenase are determinants in the action of nonsteroidal antiinflammatory agents.

Evidence is presented to show that nonsteroidal antiinflammatory drugs react with two sites on the cyclooxygenase (8,11,14-eicosatrienoate, hydrogen-donor:oxygen oxidoreductase, EC 1.14.99.1). Although the degree of interaction with the catalytic site determines the potency of such compounds, intera...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Humes, J L, Winter, C A, Sadowski, S J, Kuehl, F A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1981
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319281/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6787598/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.4.2053
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