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Multiple sites on prostaglandin cyclooxygenase are determinants in the action of nonsteroidal antiinflammatory agents.

Evidence is presented to show that nonsteroidal antiinflammatory drugs react with two sites on the cyclooxygenase (8,11,14-eicosatrienoate, hydrogen-donor:oxygen oxidoreductase, EC 1.14.99.1). Although the degree of interaction with the catalytic site determines the potency of such compounds, intera...

詳細記述

保存先:
書誌詳細
主要な著者: Humes, J L, Winter, C A, Sadowski, S J, Kuehl, F A
フォーマット: Artigo
言語:Inglês
出版事項: 1981
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC319281/
https://ncbi.nlm.nih.gov/pubmed/6787598
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