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Rescue of HIV-1 Broad Neutralizing Antibody-Expressing B cells in 2F5 V(H)xV(L) Knockin Mice Reveals Multiple Tolerance Controls()
The HIV-1 broad neutralizing antibody (bnAb) 2F5 has been shown to be poly/self-reactive in vitro, and we previously demonstrated that targeted expression of its VDJ rearrangement alone was sufficient to trigger a profound B cell developmental blockade in 2F5 V(H) knockin (KI) mice, consistent with...
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| Auteurs principaux: | , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3192533/ https://ncbi.nlm.nih.gov/pubmed/21908739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101633 |
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