The Nasal Dendritic Cell-Targeting Flt3 Ligand as a Safe Adjuvant Elicits Effective Protection against Fatal Pneumococcal Pneumonia

We have previously shown that a pneumococcal surface protein A (PspA)-based vaccine containing DNA plasmid encoding the Flt3 ligand (FL) gene (pFL) as a nasal adjuvant prevented nasal carriage of Streptococcus pneumoniae. In this study, we further investigated the safety and efficacy of this nasal v...

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Main Authors: Kataoka, Kosuke, Fujihashi, Kohtaro, Oma, Keita, Fukuyama, Yoshiko, Hollingshead, Susan K., Sekine, Shinichi, Kawabata, Shigetada, Ito, Hiro-O, Briles, David E., Oishi, Kazunori
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2011
Teme:
Microbial Immunity and Vaccines
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191952/
https://ncbi.nlm.nih.gov/pubmed/21536790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01360-10
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