A Novel Adenovirus Expressing Flt3 Ligand Enhances Mucosal Immunity by Inducing Mature Nasopharyngeal-Associated Lymphoreticular Tissue Dendritic Cell Migration

Previously, we showed that nasal administration of a naked cDNA plasmid expressing Flt3 ligand (FL) cDNA (pFL) enhanced CD4(+) Th2-type, cytokine-mediated mucosal immunity and increased lymphoid-type dendritic cell (DC) numbers. In this study, we investigated whether targeting nasopharyngeal-associa...

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Main Authors: Sekine, Shinichi, Kataoka, Kosuke, Fukuyama, Yoshiko, Adachi, Yasuo, Davydova, Julia, Yamamoto, Masato, Kobayashi, Ryoki, Fujihashi, Keiko, Suzuki, Hideaki, Curiel, David T., Shizukuishi, Satoshi, McGhee, Jerry R., Fujihashi, Kohtaro
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587249/
https://ncbi.nlm.nih.gov/pubmed/18523277
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