A Combination of Flt3 Ligand cDNA and CpG ODN as Nasal Adjuvant Elicits NALT Dendritic Cells for Prolonged Mucosal Immunity

We explore cellular and molecular mechanisms of nasal adjuvant of a combination of a plasmid encoding the Flt3 ligand cDNA (pFL) and CpG oligodeoxynucleotides (CpG ODN). The double DNA adjuvant given with OVA maintained prolonged OVA-specific secretory IgA (S-IgA) Ab responses in external secretions...

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Main Authors: Fukuiwa, Tatsuya, Sekine, Shinichi, Kobayashi, Ryoki, Suzuki, Hideaki, Kataoka, Kosuke, Gilbert, Rebekah S., Kurono, Yuichi, Boyaka, Prosper N., Krieg, Arthur M., McGhee, Jerry R., Fujihashi, Kohtaro
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2601556/
https://ncbi.nlm.nih.gov/pubmed/18625280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2008.06.091
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