Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors

In bile duct-ligated (BDL) rats, large cholangiocytes proliferate by activation of cAMP-dependent signaling. Melatonin, which is secreted from pineal gland as well as extrapineal tissues, regulates cell mitosis by interacting with melatonin receptors (MT1 and MT2) modulating cAMP and clock genes. In...

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Main Authors: Renzi, Anastasia, Glaser, Shannon, DeMorrow, Sharon, Mancinelli, Romina, Meng, Fanyin, Franchitto, Antonio, Venter, Julie, White, Mellanie, Francis, Heather, Han, Yuyan, Alvaro, Domenico, Gaudio, Eugenio, Carpino, Guido, Ueno, Yoshiyuki, Onori, Paolo, Alpini, Gianfranco
格式: Artigo
語言:Inglês
出版: American Physiological Society 2011
主題:
Liver and Biliary Tract
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191552/
https://ncbi.nlm.nih.gov/pubmed/21757639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00206.2011
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