Knockout of the neurokinin-1 receptor reduces cholangiocyte proliferation in bile duct-ligated mice

In bile duct-ligated (BDL) rats, cholangiocyte proliferation is regulated by neuroendocrine factors such as α-calcitonin gene-related peptide (α-CGRP). There is no evidence that the sensory neuropeptide substance P (SP) regulates cholangiocyte hyperplasia. Wild-type (WT, (+/+)) and NK-1 receptor (NK...

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Detalhes bibliográficos
Main Authors: Glaser, Shannon, Gaudio, Eugenio, Renzi, Anastasia, Mancinelli, Romina, Ueno, Yoshiyuki, Venter, Julie, White, Mellanie, Kopriva, Shelley, Chiasson, Valorie, DeMorrow, Sharon, Francis, Heather, Meng, Fanyin, Marzioni, Marco, Franchitto, Antonio, Alvaro, Domenico, Supowit, Scott, DiPette, Donald J., Onori, Paolo, Alpini, Gianfranco
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154601/
https://ncbi.nlm.nih.gov/pubmed/21596993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00418.2010
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