Glucocorticoid Elevation of Dexamethasone-induced Gene 2 (Dig2/RTP801/REDD1) Protein Mediates Autophagy in Lymphocytes

Glucocorticoid hormones, including dexamethasone, induce apoptosis in lymphocytes and consequently are used clinically as chemotherapeutic agents in many hematologic malignancies. Dexamethasone also induces autophagy in lymphocytes, although the mechanism is not fully elucidated. Through gene expres...

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Hauptverfasser: Molitoris, Jason K., McColl, Karen S., Swerdlow, Sarah, Matsuyama, Mieko, Lam, Minh, Finkel, Terri H., Matsuyama, Shigemi, Distelhorst, Clark W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191057/
https://ncbi.nlm.nih.gov/pubmed/21733849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.245423
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