RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer’s disease

RTP801/REDD1 is a stress-regulated protein whose upregulation is necessary and sufficient to trigger neuronal death. Its downregulation in Parkinson’s and Huntington’s disease models ameliorates the pathological phenotypes. In the context of Alzheimer’s disease (AD), the coding gene for RTP801, DDIT...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Pérez-Sisqués, Leticia, Sancho-Balsells, Anna, Solana-Balaguer, Júlia, Campoy-Campos, Genís, Vives-Isern, Marcel, Soler-Palazón, Ferran, Anglada-Huguet, Marta, López-Toledano, Miguel-Ángel, Mandelkow, Eva-Maria, Alberch, Jordi, Giralt, Albert, Malagelada, Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8206344/
https://ncbi.nlm.nih.gov/pubmed/34131105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03899-y
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