Apoptosis inhibition by Bcl-2 gives way to autophagy in glucocorticoid-treated lymphocytes

Glucocorticosteroid hormones, including prednisone and dexamethasone (Dex), have been used to treat lymphoid malignancies for many years because they readily induce apoptosis in immature lymphocytes lacking Bcl-2. However, elevated expression of the anti-apoptotic protein Bcl-2 inhibits apoptosis an...

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Hauptverfasser: Swerdlow, Sarah, McColl, Karen, Rong, Yiping, Lam, Minh, Gupta, Anu, Distelhorst, Clark W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2008
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625121/
https://ncbi.nlm.nih.gov/pubmed/18362516
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