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Glucocorticoid-Mediated Repression of the Oncogenic microRNA Cluster miR-17∼92 Contributes to the Induction of Bim and Initiation of Apoptosis

Synthetic glucocorticoids were one of the first effective treatments for lymphoid malignancies because of their ability to induce apoptosis and are still used in combination with other chemotherapeutic agents. Up-regulation of Bim, a proapoptotic member of the B-cell lymphoma-2 family, is an importa...

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Autors principals: Molitoris, Jason K., McColl, Karen S., Distelhorst, Clark W.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045743/
https://ncbi.nlm.nih.gov/pubmed/21239610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0402
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