Incomplete Folding upon Binding Mediates Cdk4/Cyclin D Complex Activation by Tyrosine Phosphorylation of Inhibitor p27 Protein

p27(Kip1) (p27), an intrinsically disordered protein, regulates the various Cdk/cyclin complexes that control cell cycle progression. The kinase inhibitory domain of p27 contains a cyclin-binding subdomain (D1), a Cdk-binding subdomain (D2), and a linker helix subdomain that connects D1 and D2. Here...

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Detalhes bibliográficos
Main Authors: Ou(欧, Li, 力), Ferreira, Antonio M., Otieno, Steve, Xiao(肖, Limin, 利民), Bashford, Donald, Kriwacki, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191053/
https://ncbi.nlm.nih.gov/pubmed/21715330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.244095
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