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Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21

Traditionally, well-defined three-dimensional structure was thought to be essential for protein function. However, myriad biological functions are performed by highly dynamic, intrinsically disordered proteins (IDPs). IDPs often fold upon binding their biological targets and frequently exhibit “bind...

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Bibliografski detalji
Glavni autori: Wang, Yuefeng, Fisher, John C., Mathew, Rose, Ou, Li, Otieno, Steve, Sublett, Jack, Xiao, Limin, Chen, Jianhan, Roussel, Martine F., Kriwacki, Richard W.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124363/
https://ncbi.nlm.nih.gov/pubmed/21358637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.536
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