Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect

Phosphatidic acid (PA) is a critical mediator of mitogenic activation of mammalian target of rapamycin complex 1 (mTORC1) signaling, a master regulator of mammalian cell growth and proliferation. The mechanism by which PA activates mTORC1 signaling has remained unknown. Here, we report that PA selec...

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Bibliografiske detaljer
Main Authors: Yoon, Mee-Sup, Sun, Yuting, Arauz, Edwin, Jiang, Yu, Chen, Jie
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190997/
https://ncbi.nlm.nih.gov/pubmed/21737445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.262816
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