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Polymorphic Triple β-Sheet Structures Contribute to Amide Hydrogen/Deuterium (H/D) Exchange Protection in the Alzheimer Amyloid β42 Peptide

Characterization of the polymorphic structural range of Aβ oligomers is important to the understanding of the mechanisms of toxicity. Yet for highly polymorphic ensembles, experimental structural elucidation is difficult. Here, we use a combination of NMR solvent protection experiments and computati...

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Detalles Bibliográficos
Main Authors: Ma, Buyong, Nussinov, Ruth
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190809/
https://ncbi.nlm.nih.gov/pubmed/21832091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.241141
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