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Polymorphic Triple β-Sheet Structures Contribute to Amide Hydrogen/Deuterium (H/D) Exchange Protection in the Alzheimer Amyloid β42 Peptide

Characterization of the polymorphic structural range of Aβ oligomers is important to the understanding of the mechanisms of toxicity. Yet for highly polymorphic ensembles, experimental structural elucidation is difficult. Here, we use a combination of NMR solvent protection experiments and computati...

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Sonraí Bibleagrafaíochta
Main Authors: Ma, Buyong, Nussinov, Ruth
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190809/
https://ncbi.nlm.nih.gov/pubmed/21832091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.241141
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