載入...

Modeling the Alzheimer Aβ(17-42) Fibril Architecture: Tight Intermolecular Sheet-Sheet Association and Intramolecular Hydrated Cavities

We investigate Aβ(17-42) protofibril structures in solution using molecular dynamics simulations. Recently, NMR and computations modeled the Aβ protofibril as a longitudinal stack of U-shaped molecules, creating an in-parallel β-sheet and loop spine. Here we study the molecular architecture of the f...

全面介紹

Na minha lista:
書目詳細資料
Main Authors: Zheng, Jie, Jang, Hyunbum, Ma, Buyong, Tsai, Chung-Jun, Nussinov, Ruth
格式: Artigo
語言:Inglês
出版: The Biophysical Society 2007
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2025669/
https://ncbi.nlm.nih.gov/pubmed/17675353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.110700
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!