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Modeling the Alzheimer Aβ(17-42) Fibril Architecture: Tight Intermolecular Sheet-Sheet Association and Intramolecular Hydrated Cavities
We investigate Aβ(17-42) protofibril structures in solution using molecular dynamics simulations. Recently, NMR and computations modeled the Aβ protofibril as a longitudinal stack of U-shaped molecules, creating an in-parallel β-sheet and loop spine. Here we study the molecular architecture of the f...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Biophysical Society
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2025669/ https://ncbi.nlm.nih.gov/pubmed/17675353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.110700 |
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