Inducible Nitric-oxide Synthase and Nitric Oxide Donor Decrease Insulin Receptor Substrate-2 Protein Expression by Promoting Proteasome-dependent Degradation in Pancreatic β-Cells: INVOLVEMENT OF GLYCOGEN SYNTHASE KINASE-3β

Insulin receptor substrate-2 (IRS-2) plays a critical role in the survival and function of pancreatic β-cells. Gene disruption of IRS-2 results in failure of the β-cell compensatory mechanism and diabetes. Nonetheless, the regulation of IRS-2 protein expression in β-cells remains largely unknown. In...

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Hlavní autoři: Tanioka, Toshihiro, Tamura, Yoshiaki, Fukaya, Makiko, Shinozaki, Shohei, Mao, Ji, Kim, Minhye, Shimizu, Nobuyuki, Kitamura, Tadahiro, Kaneki, Masao
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190744/
https://ncbi.nlm.nih.gov/pubmed/21700708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.192732
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