Liver-specific Inducible Nitric-oxide Synthase Expression Is Sufficient to Cause Hepatic Insulin Resistance and Mild Hyperglycemia in Mice

Inducible nitric-oxide synthase (iNOS), a major mediator of inflammation, plays an important role in obesity-induced insulin resistance. Inhibition of iNOS by gene disruption or pharmacological inhibitors reverses or ameliorates obesity-induced insulin resistance in skeletal muscle and liver in mice...

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Detalhes bibliográficos
Main Authors: Shinozaki, Shohei, Choi, Cheol Soo, Shimizu, Nobuyuki, Yamada, Marina, Kim, Minhye, Zhang, Ting, Dong, H. Henry, Kim, Young-Bum, Kaneki, Masao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186386/
https://ncbi.nlm.nih.gov/pubmed/21846719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.187666
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