Protective effects of a nicotinamide derivative, isonicotinamide, against streptozotocin-induced β-cell damage and diabetes in mice

OBJECTIVE: Nicotinamide rescues β-cell damage and diabetes in rodents, but a large-scale clinical trial failed to show the benefit of nicotinamide in the prevention of type 1 diabetes. Recent studies have shown that Sirt1 deacetylase, a putative protector of β-cells, is inhibited by nicotinamide. We...

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Detalhes bibliográficos
Main Authors: Fukaya, Makiko, Tamura, Yoshiaki, Chiba, Yuko, Tanioka, Toshihiro, Mao, Ji, Inoue, Yoko, Yamada, Marina, Waeber, Christian, Ido-Kitamura, Yukari, Kitamura, Tadahiro, Kaneki, Masao
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084867/
https://ncbi.nlm.nih.gov/pubmed/24246675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.11.024
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