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Farnesyltransferase inhibitor improved survival following endotoxin challenge in mice
Endotoxemia plays an important role in the pathogenesis of sepsis and is accompanied by dysregulated apoptosis of immune and non-immune cells. Treatment with statins reduces mortality in rodent models of sepsis and endotoxemia. Inhibition of protein isoprenylation, including farnesylation, has been...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2813732/ https://ncbi.nlm.nih.gov/pubmed/20034462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.12.094 |
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