Farnesyltransferase Inhibitor FTI-277 Reduces Mortality of Septic Mice along with Improved Bacterial Clearance

Treatment with statins, inhibitors of HMG-CoA reductase, extends the survival of septic mice. However, the molecular mechanisms underlying the cholesterol-lowering, independent beneficial effects of statins in sepsis are poorly understood. The inhibition of protein isoprenylation, namely farnesylati...

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Main Authors: Yang, Wen, Yamada, Marina, Tamura, Yoshiaki, Chang, Kyungho, Mao, Ji, Zou, Lin, Feng, Yan, Kida, Kotaro, Scherrer-Crosbie, Marielle, Chao, Wei, Ichinose, Fumito, Yu, Yong-Ming, Fischman, Alan J., Tompkins, Ronald G., Yao, Shanglong, Kaneki, Masao
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Inflammation, Immunopharmacology, and Asthma
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226365/
https://ncbi.nlm.nih.gov/pubmed/21873557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.183558
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