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Selective Water-Soluble Gelatinase Inhibitor Prodrugs
SB-3CT (1), a selective and potent thiirane-based gelatinase inhibitor, is effective in animal models of cancer metastasis and stroke; however, it is limited by poor aqueous solubility and extensive metabolism. We addressed these issues by blocking the primary site of metabolism and capitalizing on...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3190643/ https://ncbi.nlm.nih.gov/pubmed/21866961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200566e |
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