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Intermolecular structure determination of amyloid fibrils with magic-angle spinning and dynamic nuclear polarization NMR

We describe magic-angle spinning NMR experiments designed to elucidate the interstrand architecture of amyloid fibrils. Three methods are introduced for this purpose, two being based on the analysis of long-range (13)C-(13)C correlation spectra and a third based on the identification of intermolecul...

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Detalhes bibliográficos
Main Authors: Bayro, Marvin J., Debelouchina, Galia T., Eddy, Matthew T., Birkett, Neil R., MacPhee, Catherine E., Rosay, Melanie, Maas, Werner E., Dobson, Christopher M., Griffin, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190134/
https://ncbi.nlm.nih.gov/pubmed/21774549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja203756x
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