Viral Double-Strand RNA-Binding Proteins Can Enhance Innate Immune Signaling by Toll-Like Receptor 3

Toll-like Receptor 3 (TLR3) detects double-stranded (ds) RNAs to activate innate immune responses. While poly(I:C) is an excellent agonist for TLR3 in several cell lines and in human peripheral blood mononuclear cells, viral dsRNAs tend to be poor agonists, leading to the hypothesis that additional...

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Detalhes bibliográficos
Main Authors: Lai, Yvonne, Yi, Guanghui, Chen, Alice, Bhardwaj, Kanchan, Tragesser, Brady J., Rodrigo A. Valverde, Zlotnick, Adam, Mukhopadhyay, Suchetana, Ranjith-Kumar, C. T., Kao, C. Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189932/
https://ncbi.nlm.nih.gov/pubmed/22016778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025837
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