Crystal structure and enzymatic characterization of thymidylate synthase X from Helicobacter pylori strain SS1

Thymidylate synthase X (ThyX) catalyzes the methylation of dUMP to form dTMP in bacterial life cycle and is regarded as a promising target for antibiotics discovery. Helicobacter pylori is a human pathogen associated with a number of human diseases. Here, we cloned and purified the ThyX enzyme from...

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Hlavní autoři: Wang, Kuifeng, Wang, Qi, Chen, Jing, Chen, Lili, Jiang, Hualiang, Shen, Xu
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley Subscription Services, Inc., A Wiley Company 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189525/
https://ncbi.nlm.nih.gov/pubmed/21633987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.668
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