Emodin targets the β-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization

BACKGROUND: The natural product Emodin demonstrates a wide range of pharmacological properties including anticancer, anti-inflammatory, antiproliferation, vasorelaxant and anti-H. pylori activities. Although its H. pylori inhibition was discovered, no acting target information against Emodin has bee...

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Bibliographic Details
Main Authors: Chen, Jing, Zhang, Liang, Zhang, Yu, Zhang, Haitao, Du, Jiamu, Ding, Jianping, Guo, Yuewei, Jiang, Hualiang, Shen, Xu
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
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Research article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692856/
https://ncbi.nlm.nih.gov/pubmed/19433000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-9-91
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