The class-I HDAC inhibitor MGCD0103 induces apoptosis in Hodgkin lymphoma cell lines and synergizes with proteasome inhibitors by an HDAC6-independent mechanism

Inhibition of histone deacetylase 6 (HDAC6)-dependent aggresome function by pan HDAC inhibitors was recently reported to be a key mechanism underlying the synergistic activity between proteasome inhibitors and HDAC inhibitors in a variety of tumour types. Because these combinations induce significan...

Full description

Saved in:
Bibliographic Details
Main Authors: Buglio, Daniela, Mamidipudi, Vidya, Khaskhely, Noor M., Brady, Helen, Heise, Carla, Besterman, Jeffrey, Martell, Robert E., MacBeth, Kyle, Younes, Anas
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189488/
https://ncbi.nlm.nih.gov/pubmed/20880107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2010.08342.x
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items